SARS-CoV-2 - Spike protein - Primary antibodies
The SARS-CoV-2 virus, the cause of the current Covid-19 pendemia, can infect human respiratory epithelial cells through an interaction with the human ACE2 receptor or angiotensin converting enzyme receptor 2. SARS-CoV-2 has on its surface a protein called Spike or S protein. This type I transmembrane protein is present on the viral envelope in the form of a homotrimer. Each monomer consists of 2 subunits, S1 and S2. The S1 subunit contains a receptor binding domain (RBD) which binds to the ACE2 receptor on the host membrane. The S2 sub-unit is activated by the bond between S1 and the ACE2 receptor and contains the elements necessary for membrane fusion. The S protein thus plays an important role in the infection of SARS-CoV-2 as well as in the induction of neutralizing antibody and T cell responses and in protective immunity.
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RUOCE / IVD
- Unconjugated 1373
- Biotin 62
- HRP 42
- FITC 11
- PE 2
- Gold 1
- virus 990
- human 139
- mouse 70
- rabbit 8
- all species 3
- monkey 2
- Primary antibody
- rabbit 688
- mouse 400
- human 335
- chicken 22
- goat 21
- llama 5
- monkey 2
- sars-cov-2 2
- virus 1
- ELISA 1345
- WB 608
- IF 216
- Neutralization 136
- FC 112
- IP 108
- ICC 104
- IHC 60
- Assay 47
- Chemiluminescence 18
- FA 10
- Immunoassay 8
- Dot blot 5
- Chromatography 2
- Detection 2
- Lateral Flow 1
- Polyclonal 451
- Monoclonal 231
- S 30
- CR3022 25
- D001 15
- D004 15
- 5D9 13
- A1 13
- AM122 12
- D006 12
- 7 10
- DM24 9
- DM25 9
- H6 9
- RH-01 9
- RH-02 9
- AM130 8
- D003 8
- DM39 8
- DM40 8
- DM41 8
- CB6 7
- D005 7
- MAbs in vitro: R107 7
- MAbs in vivo: RBD1106 7
- RBD1125 7
- 118 6
- 34-G3 6
- 43 6
- Q25-L 6
- 5E8 5
- ABM19C9 5
- AM001414 (414-1) 5
- AM002414 (414-2) 5
- AM004414 (414-4) 5
- AM043105 (105-43) 5
- DM26 5
- DM27 5
- DM35 5
- DM42 5
- OTI1C2 5
- OTI1H6 5
- OTI5A7 5
- R007 5
- 2146 4
- 2165 4
- 2196 4
- 5E12 4
- ABM5D1.1E8 4
- AD10.F6.G3.E3 4
- D002 4
- REGN10933 4
- REGN10987 4
- 001 3
- 003 3
- 05 3
- 1 3
- 117 3
- 135 3
- 16-F-28 3
- 17 3
- 18C7B10 3
- 19-J-16 3
- 190 3
- 1G8D11 3
- 20C3G5 3
- 23-D-12 3
- 235 3
- 4 3
- 41 3
- 42 3
- 45 3
- 48 3
- 493 3
- 4A3 3
- 4A8 3
- 505 3
- 55 3
- 5A7 3
- 7A4D12 3
- 7C11H11 3
- 831 3
- 8A1G8 3
- 9F7E4 3
- ABMX-002 3
- AM009105 (105-9) 3
- AM038105 (105-38) 3
- AbA128 3
- AbA205 3
- AbB101 3
- AbB501 3
- AbB505 3
- AbB606 3
- AbD102 3
- AbD103 3
- AbD704 3
- AbD802 3
- AbE450 3
- AbF712 3
- AbF804 3
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