General Info
| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Lecithin retinol acyltransferase (111-160 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | LRAT |
| Gene ID: | 9227 |
| Uniprot ID: | LRAT_HUMAN |
| Immunogen Region: | 111-160 aa |
| Specificity: | LRAT Polyclonal Antibody detects endogenous levels of LRAT protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human LRAT at the amino acid range 111-160 |
Description
| Function | Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium.due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology. |
| Protein Name | Lecithin Retinol AcyltransferasePhosphatidylcholine--Retinol O-Acyltransferase |
| Database Links | Reactome: R-HSA-2453864Reactome: R-HSA-2453902Reactome: R-HSA-975634 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinRough Endoplasmic ReticulumEndosomeMultivesicular BodyCytoplasmPerinuclear RegionPresent In The Rough Endoplasmic Reticulum And Multivesicular Body In Hepatic Stellate CellsPresent In The Rough Endoplasmic Reticulum And Perinuclear Region In Endothelial Cells |
| Alternative Antibody Names | Anti-Lecithin Retinol Acyltransferase antibodyAnti-Phosphatidylcholine--Retinol O-Acyltransferase antibodyAnti-LRAT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance