Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Thiocolchicine [2730-71-4]
Katalog-Nummer T41248-2mg
Size : 2mg
Marke : TargetMol
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Thiocolchicine
Catalog No. T41248 CAS 2730-71-4
Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 µM and a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.
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Thiocolchicine, CAS 2730-71-4
| Description | Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 µM and a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology. |
| Targets&IC50 | Tubulin polymerization:0.7 µM(Ki), Tubulin polymerization:2.5 µM |
| In vitro | Thiocolchicine (1 nM-100 μM; 24-72 hours) shows a relationship between cell cycle blocking activity and growth inhibition in breast cancer cells. Thiocolchicine inhibits cell proliferation of MDA-MB-231 and multidrug-resistant (MDR) MCF-7 ADRr breast cancer cells with IC50s of 0.6 nM and 400 nM, respectively, as well as MDR CEM-VBL leukemia cells with an IC50 of 50 nM[1]. Thiocolchicine is against MCF-7, LoVo, LoVo/DX, A-549 and BALB/3T3 cells with IC50 values of 0.01 μM, 0.021 μM, 0.398 μM, 0.011 μM and 0.114 μM, respectively[2]. |
| Molecular Weight | 415.5 |
| Formula | C22H25NO5S |
| CAS No. | 2730-71-4 |
Storage
Solubility Information
DMSO: 95 mg/mL (228.64 mM), Sonication is recommended.
References and Literature
1. R De Vincenzo, et al. Antiproliferative Activity of Colchicine Analogues on MDR-positive and MDR-negative Human Cancer Cell Lines. Anticancer Drug Des. 1998 Jan;13(1):19-33. 2. Klaus M.Hahn, et al. Structural requirements for the binding of colchicine analogs to tubulin: the role of the C-10 substituent. Bioorganic & Medicinal Chemistry Letters.Volume 1, Issue 9, 1991, Pages 471-476