keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
P110 TFA [TP1947L]
Katalog-Nummer TP1947L-25mg
Size : 25mg
Marke : TargetMol
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P110 TFA
Catalog No. TP1947L CAS TP1947L
P110 TFA is a dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity.
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P110 TFA, CAS TP1947L
| Description | P110 TFA is a dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. |
| In vitro | P110 TFA Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins.?Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro.?Reduces programmed cell death and improves cell viability by protecting mitochondrial integrity.?Reduces mitochondrial fragmentation and mitochondrial ROS production in mouse model of Parkinson's disease.?Cell permeable. |
| Molecular Weight | 2525.8 |
| Formula | C102H180F3N45O27 |
| CAS No. | TP1947L |
Storage
Solubility Information
DMSO: 50 mg/mL, Sonication is recommended.
H2O: 50 mg/mL, Sonication is recommended.
References and Literature
1. Qi et al (2013) A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J.Cell Sci. 126 789 PMID: 2. Filichia et al (2016) Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTP. Sci.Rep. 13 32656 PMID: