Ipilimumab [477202-00-9]
Katalog-Nummer HY-P9901-1mg
Size : 1mg
Marke : MedChemExpress
Ipilimumab is a fully human monoclonal antibody IgG1κ that blocks the inhibitory receptor cytotoxic T lymphocyte antigen 4 (CTLA-4) on T cells. Ipilimumab can be used in unresectable or metastatic melanoma (MM) studies.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
Ipilimumab Chemische Struktur
CAS. Nr. : 477202-00-9
This product is a controlled substance and not for sale in your territory.
Based on 3 publication(s) in Google Scholar
Beschreibung |
Ipilimumab is a fully human monoclonal antibody IgG1κ that blocks the inhibitory receptor cytotoxic T lymphocyte antigen 4 (CTLA-4) on T cells. Ipilimumab can be used in unresectable or metastatic melanoma (MM) studies[1]. |
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Isotype |
Human IgG1 kappa |
Recommend Isotype Controls |
Human IgG1 kappa, Isotype Control |
Species |
Human |
In Vitro |
Ipilimumab inhibits CTLA-4, allowing the T cell immune response to be reactivated against tumor cells. Ipilimumab can promote antitumor activity as a single agent or in combination with cytokines, chemotherapy, or vaccines[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
In Vivo |
Ipilimumab (i.v., 3 or 10 mg/kg, once a week for 4 weeks) combination with nivolumab (10 or 50 mg/kg) results in gastrointestinal inflammation in crab-eating monkeys and is associated with reduced albumin, increases globulin and increases neutrophil and eosinophil counts and mononuclear inflammation of the large intestine. Recurrent diarrhoea is demonstrated in the high-dose group, which also has visible degranulation of glandular blast cells in the pancreas[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
Klinische Studie |
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Molekulargewicht |
145313.36 |
CAS. Nr. |
477202-00-9 |
Appearance |
Liquid |
Color |
Colorless to light yellow |
SMILES |
[Ipilimumab] |
Versand | Shipping with dry ice. |
Speicherung |
Please store the product under the recommended conditions in the Certificate of Analysis. |
Reinheit & Dokumentation |
Purity: 99.88% |
Verweise |
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Ipilimumab Related Classifications
- Immunology/Inflammation
- CTLA-4
Molaritätsrechner
Verdünnungsrechner
Die Formel zur Berechnung von Molaritäten
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
Ipilimumab477202-00-9MDX-010 BMS-734016MDX010MDX 010BMS734016BMS 734016BMS-734016CTLA-4Cytotoxic T-lymphocyte-associated protein 4CD152IgG1κmetastatic melanomaInhibitorinhibitorinhibit