OABB00475 | COL4A2 Antibody Biotrend

Datasheets/Manuals	Printable datasheet for IRF3 Recombinant Antibody [4H10] (OACA12158)

Product Info
Predicted Species Reactivity	Human
Product Format	Liquid
Clonality	Recombinant Monoclonal
Conjugation	Unconjugated
Application	Enzyme-linked immunosorbent assay, Western blot
Reconstitution and Storage	-20°C or -80°C
Immunogen	A synthesized peptide derived from human Phospho-IRF3 (S386)
Purification	Affinity Purified

Gene Symbol	IRF3
Gene Full Name	interferon regulatory factor 3
Alias Symbols	IIAE7;interferon regulatory factor 3.
NCBI Gene Id	3661
Protein Name	Interferon regulatory factor 3
Description of Target	Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
Uniprot ID	Q14653

COL4A2 Antibody