- More Files
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using CDKN1B polyclonal antibody (Cat # PAB18369).
Peptide "+" means "peptide blocking".
- Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CDKN1B.
Immunogen
A synthetic peptide corresponding to human CDKN1B.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to CDKN1B.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using CDKN1B polyclonal antibody (Cat # PAB18369).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
- Gene Info — CDKN1B
Entrez GeneID
1027Protein Accession#
P46527Gene Name
CDKN1B
Gene Alias
CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Gene Description
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Gene Ontology
HyperlinkGene Summary
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq
Other Designations
cyclin-dependent kinase inhibitor 1B
- Interactome
- Pathway
- Disease
- Publication Reference
- Expression of cyclin-dependent kinase inhibitor p27(Kip1) in AIDS-related diffuse large-cell lymphomas is associated with Epstein-Barr virus-encoded latent membrane protein 1.
Gloghini A, Gaidano G, Larocca LM, Pierconti F, Cingolani A, Dal Maso L, Capello D, Franceschi S, Tirelli U, Libra M, Niu H, Dalla-Favera R, Carbone A.
The American Journal of Pathology 2002 Jul; 161(1):163.
Application：IHC-P, WB-Tr, Human, Ramos cells, Lymphoid.
- Expression of cyclin-dependent kinase inhibitor p27(Kip1) in AIDS-related diffuse large-cell lymphomas is associated with Epstein-Barr virus-encoded latent membrane protein 1.