B7 H6 (NCR3LG1) Human Gene Knockout Kit (CRISPR)

CAT#: KN232774RB

NCR3LG1 - human gene knockout kit via CRISPR, HDR mediated



HDR-mediated knockout kit validation

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Specifications

Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Donor DNA RFP-BSD
Symbol B7 H6
Locus ID 374383
Components

KN232774G1, B7 H6 gRNA vector 1 in pCas-Guide CRISPR vector

KN232774G2, B7 H6 gRNA vector 2 in pCas-Guide CRISPR vector

KN232774RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001202439, NM_001009913, NR_026750
UniProt ID Q68D85
Synonyms B7-H6; B7H6; DKFZp686O24166
Summary B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]

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