General Info
Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-WLS (43-232) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | WLS |
Gene ID: | 79971 |
Uniprot ID: | WLS_HUMAN |
Immunogen Region: | 43-232 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 43-232 of human WLS (NP_001002292.3). |
Immunogen Sequence: | YMSVKCVDARKNHHKTKWFV PWGPNHCDKIRDIEEAIPRE IEANDIVFSVHIPLPHMEMS PWFQFMLFILQLDIAFKLNN QIRENAEVSMDVSLAYRDDA FAEWTEMAHERVPRKLKCTF TSPKTPEHEGRYYECDVLPF MEIGSVAHKFYLLNIRLPVN EKKKINVGIGEIKDIRLVGI HQNGGFTKVW |
Description
Post Translational Modifications | N-glycosylated. |
Function | Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development. |
Protein Name | Protein Wntless HomologIntegral Membrane Protein Gpr177Protein Evenness Interrupted HomologEviPutative Nf-Kappa-B-Activating Protein 373 |
Database Links | Reactome: R-HSA-3238698 |
Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembraneCell MembraneEndoplasmic Reticulum MembraneEarly Endosome MembraneCo-Localizes With The Adaptin Ap2a2 At Distinct Punctae |
Alternative Antibody Names | Anti-Protein Wntless Homolog antibodyAnti-Integral Membrane Protein Gpr177 antibodyAnti-Protein Evenness Interrupted Homolog antibodyAnti-Evi antibodyAnti-Putative Nf-Kappa-B-Activating Protein 373 antibodyAnti-WLS antibodyAnti-C1orf139 antibodyAnti-GPR177 antibodyAnti-UNQ85 antibodyAnti-PRO18667 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance