General Info
| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Tyrosine-protein phosphatase non-receptor type 22 (N-Term) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | PTPN22 |
| Gene ID: | 26191 |
| Uniprot ID: | PTN22_HUMAN |
| Immunogen Region: | N-Term |
| Specificity: | PTP22 Polyclonal Antibody detects endogenous levels of PTP22 protein. |
| Immunogen: | Synthesized peptide derived from the N-terminal region of human PTP22. |
Description
| Post Translational Modifications | Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases. |
| Function | Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Promotes host antiviral responses mediated by type 1 interferon. Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy. Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3. Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide). |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 22Hematopoietic Cell Protein-Tyrosine Phosphatase 70z-PepLymphoid PhosphataseLypPest-Domain PhosphatasePep |
| Database Links | Reactome: R-HSA-202427Reactome: R-HSA-202430 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 antibodyAnti-Hematopoietic Cell Protein-Tyrosine Phosphatase 70z-Pep antibodyAnti-Lymphoid Phosphatase antibodyAnti-Lyp antibodyAnti-Pest-Domain Phosphatase antibodyAnti-Pep antibodyAnti-PTPN22 antibodyAnti-PTPN8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance