Adssl1 Mouse Gene Knockout Kit (CRISPR)

CAT#: KN300941

Adssl1 - mouse gene knockout kit via CRISPR, HDR mediated



HDR-mediated knockout kit validation

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Specifications

Product Data
Format 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
Donor DNA GFP-puro
Symbol Adssl1
Locus ID 11565
Components

KN300941G1, Adssl1 gRNA vector 1 in pCas-Guide CRISPR vector

KN300941G2, Adssl1 gRNA vector 2 in pCas-Guide CRISPR vector

KN300941D, donor DNA containing left and right homologous arms and GFP-puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_007421
UniProt ID P28650
Synonyms Adss; Adss1; AI528595
Summary Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.[UniProtKB/Swiss-Prot Function]

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