Data Sheet Specifications:
Description
Nonhuman primates (NHP) resemble humans in multiple ways including similarities in genomics, immunogenetics, and age-related changes in immune function. These characteristics are critical to the establishment of a relevant model in which to conduct preclinical studies to optimize the efficacy and safety of therapeutic approaches. Importantly, NHPs are vital preclinical models for viruses as viral infections are frequently associated with the same pathologies. Hence, NHPs are immune models to study viral vaccine efficacy and antiviral therapeutic safety and efficacy and to understand aspects of viral pathogenesis. Over numerous preclinical studies for human viral diseases, NHPs have demonstrated to be a beneficial benchmark for investigating human viral infections.MHC Monomers for detecting antigen specific t-cell populations.
| Target: | SIV |
|---|---|
| Product Type: | Monomer |
| Size: | 500 ug |
| Application: | FCM |
| Research Area / Disease: | Immune Monitoring, Immunology |
| Class: | Class I |
| Allele: | Mamu-A*01 |
| Peptide Sequence: | CTPYDINQM |
| Conjugate: | Biotin |
| Species Reactivity: | Rhesus Macaque |
| Specificity: | gag |
| Storage Temperature: | -70°C |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Peptide Sequence: | CTPYDINQM |
Citations
- Graveline, Richard, et al. “Development of a nonhuman primate challenge model to evaluate CD8+ T cell responses to an adenovirus-based vaccine expressing SIV proteins upon repeat-dose treatment with checkpoint inhibitors.” Mabs. Vol. 14. No. 1. Taylor & Francis, 2022.
- Ishii, Hiroshi, et al. “A novel immunogen selectively eliciting CD8+ T cells but not CD4+ T cells targeting immunodeficiency virus antigens.” Journal of Virology 94.8 (2020): e01876-19.