Maclura pomifera (MPL/MPA)

Maclura pomifera agglutinin or lectin (MPA/MPL) is tetrameric plant protein purified by affinity chromatography. MPA has a molecular weight of about 44,000 and consists of four subunits. It has an isoelectric point between pH 4.8 and pH 5.3, and blood group specificity towards A, B, and O (-SA). This lectin has a high affinity for tumor-associated T-antigen disaccharide (Galβ1,3GalNAcalpha; ) and many O-linked glycopeptide structures. The structure of Galβ1,3GalNAcalpha; occurs on the surface of tumor cells as a mucin-associated antigenic marker, termed as T-antigen. It is also the central element in O-linked glycopeptide structures on other mammalian glycoproteins.

Osage orange

A, B, O (-SA)

Galbeta; 3GalNAc

Galactose

None Required

Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Osage orange

Affinity purified

Supplied as a lyophilized powder.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.