Human Perforin ELISpot Pair, 10 x 96-well

CAT#: EA101822

Human Perforin ELISpot Pair, 10 x 96-well

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Product Data
Format 10 x 96-well
Assay Type Enzyme-Linked ImmunoSpot (ELISpot)
Signal Colorimetric
Specificity Recognizes natural human Perforin
Cross Reactivity No cross reactivity with other human soluble molecules
Components ELISpot matched antibody pairs are extensively validated and include pre-titrated capture antibody and biotinylated detection antibody. Antibodies are supplied in quantities sufficient for 10 x 96 samples.
Background The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Symbol PRF1
Gene ID 5551