Extemporaneous immunohistochemistry (IHC)

Extemporaneous immunohistochemistry (IHC)


The extemporaneous examination consists in performing one or more histological section (s) during an intervention in order to guide the surgical procedure as well as possible.

Many publications have indicated that receiving lab results in “ideally less than 20 minutes” is highly desirable for a variety of intraoperative surgeries (eg sentinel lymph node assessments, breast, lung, brain, and thyroid cancers). These rapid test results give physicians more information about their patients status at the time of surgery and thereby are anticipated to improve medical outcomes. Intraoperative tests performed by IHC can be a highly valuable tool but can only be practical if the entire IHC procedure can be completed in less than 20 minutes (including cutting tissue). Conventional IHC processes require hours to complete and are, therefore, impractical for intraoperative applications. The standard of practice today is to utilize hematoxylin and eosin (H&E) staining during intraoperative surgery.  With few exceptions, physicians can only make surgical decisions based solely upon the morphologies observed from the H&E stain results. As  traditional central laboratory IHC results become available days later, a patient with a false-negative may be required to return for additional surgeries with the corresponding ramifications of cost and inconvenience for the patient and medical providers.

We propose a range of primary antibodies directly coupled to an HRP polymer to achieve rapid IHC in less than 10 minutes without having to use a secondary antibody.


Target                              
Product code
-005  (5ml)
-010 (10ml)
-015 (15ml)
-030 (30ml)
K31007
Antibody
Antibody
   
   
K41026
Kit
Kit
  
  
K31038
Antibody
Antibody
  
K32029
Antibody
Antibody
  
  
K31010
Antibody
Antibody
Antibody

K42014
Kit
Kit
  
  
K42015
Kit
Kit
  
K41001
Kit
Kit
  
  
K41058
Kit
Kit
   
K31058
  
  
Antibody
  
K31040
Antibody
Antibody
  
K42002
Kit
Kit
  
K32001
Antibody
Antibody
  
  
K41009
Kit
Kit  
K41025
Kit
Kit
    
K41024
Kit
Kit   
  
K31021
Antibody
Antibody
  

Number of tests estimated with ~100 μl / Tissue :
-005 = 50 tests
-010 = 100 tests
-015 = 150 tests
-030 = 300 tests