Anti-TIM3 CE/IVD for IHC - Hematopathology

Anti-TIM3 CE/IVD for IHC - Hematopathology


T-cell Immunoglobulin and Mucin-Domain-Containing Molecule-3 (TIM3), also called Hepatitis A virus cellular receptor 2, HAVCR2, is present on T-helper type 1 lymphocytes and other immune cells including dendritic cells and natural killer cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. TIM3 is overexpressed in CD4+ tumor-infiltrating lymphocytes, including those with non-small cell lung cancer associated with poor prognoses. TIM3 has recently emerged as a potential target for cancer immunotherapy.




Kidney section

Katalog-Nummer
Beschreibung
Cond.
H. T. Preis
Monoclonal Anti-TIM3 (Clone: IHC003)
IHC003-1
 1ml,Concentrated 
Monoclonal Anti-TIM3 (Clone: IHC003)
IHC003-100
 0,1mlConcentrated 
Monoclonal Anti-TIM3 (Clone: IHC003)
IHC003-7
 7ml,prediluted