Anti-Oct-2 CE/IVD for IHC - Hematopathology
Octamer transcription factor-2 (Oct-2) is a member of the POU homeodomain family of transcription factors. It possesses a leucine zipper domain and binds to the immunoglobin gene octamer motif (5-ATTTCAT-3), thereby regulating B-cell-specific gene expression and transcription in a variety of tissues. Oct-2 is important for the expression of B-cell specific genes, such as CD20 and CRISP-3. Oct-2 is expressed highly in germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells, thus making Anti-Oct-2 useful for detecting various lymphomas including B-chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, T-cell rich B-cell lymphoma, nodular lymphocyte predominant Hodgkin’s lymphoma, and classic Hodgkin’s lymphoma.
H. T. Preis