Anti-CD8 CE/IVD for IHC - Hematopathology

Anti-CD8 CE/IVD for IHC - Hematopathology


CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that functions as a co-receptor with the T-cell receptor (TCR). The CD8 molecule consists of a heterodimer of α and β chains covalently linked by a disulfide bond, and is predominantly expressed on the surface of cytotoxic T cells. CD8 expression can also be detected on natural killer cells, cortical thymocytes, and dendritic cells.
Cytotoxic CD8+ T lymphocytes are crucial components of the adaptive immune system that execute immunosurveillance to eliminate nascent tumor cells. Upon simultaneous binding to the major histocompatibility complex (MHC) class I molecule with the TCR, cytotoxic T-cell sensitivity is increased 100-fold. CD8 is commonly expressed in T-cell large granular lymphocyte leukemia and is also co-expressed with CD4 in some T-lymphoblastic lymphoma.
Recently, detection of tumor infiltrating CD8+ lymphocytes have been correlated with favorable prognosis and improved survival in patients with colorectal, ovarian, esophageal, renal, lung and pancreatic tumors. A high CD8+/CD4+ T-cell ratio is also associated with improved survival in colon and ovarian cancer patients.





Tonsil section
Tonsil section

Katalog-Nummer
Beschreibung
Cond.
H. T. Preis
Rabbit Monoclonal Anti-CD8 (Clone: S23-D)
DB086-0.05
 50μl,Concentrated 
Rabbit Monoclonal Anti-CD8 Clone (P17-V)
DB085-0.1
 100μl,Concentrated 
Rabbit Monoclonal Anti-CD8 Clone (P17-V)
DB085-0.5
 500μl,Concentrated 
Rabbit Monoclonal Anti-CD8 Clone (P17-V)
DB085-1
 1ml,Concentrated 
Rabbit Monoclonal Anti-CD8 (Clone: P17-V)
DB085-RTU-15
 15ml,prediluted 
Rabbit Monoclonal Anti-CD8 (Clone: P17-V)
DB085-RTU-7
 7ml,prediluted 
Rabbit Monoclonal Anti-CD8 Clone (P17-V)
DB085-0.2
 200μl,Concentrated 
Rabbit Monoclonal Anti-CD8 (Clone: S23-D)
DB086-0.02
 20ul,Conentrated 
Rabbit Monoclonal Anti-CD8 (Clone: P17-V)
DB085-RTU-1
 1ml,prediluted 
Rabbit Monoclonal Anti-CD8 Clone (P17-V)
DB085-0.04
 40ul,Cencentrated 
Rabbit Monoclonal Anti-CD8 (Clone: S23-D)
DB086-0.1
 100μl,Concentrated