3D scaffold for tumor cells - Black plates (Fluorescence)

3D scaffold for tumor cells - Black plates (Fluorescence)


Extracellular matrix (ECM) is a complex viscoelastic system composed of various distinct components (GAG, Collagen…) that are often organized into a fibrillar microstructure.

The physicochemical properties (composition and architecture) of the ECM play a critical role in regulating important cellular functions such as spreading, migration, proliferation, and differentiation.

To better mimic the tumor microenvironment, BIOMIMESYS® Oncology is a double interpenetrating network (IPN) hydroscaffold based on Hyaluronic acid (HA) and type I collagen crosslinked with Adipic acid dihydrazid (ADH).

Spheroid growth, Viability, Cell proliferation

BIOMIMESYS® Oncology hydroscaffold provides cell binding sites with CD44 and RHAMM allowing cell-matrix and cell-cell interactions.

Cancer cells growing in BIOMIMESYS® Oncology hydrscaffold proliferate and aggregate to form spheroids from the 5th day of culture. The size and formation of the spheroids varies as a function of:
  • Seeding density
  • Length of culture
  • Cell type
The cells can be cultured for at least 28 days.

Katalog-Nummer
Beschreibung
Cond.
H. T. Preis
BIO_ONC_96_24_B10
 10 plates / 24 wells filled 
BIO_ONC_96_24_black
 1 plate / 24 wells filled 
BIO_ONC_96_96_B10
 10 plates / 96 wells filled 
BIO_ONC_96_96_black
 1 plate / 96 wells filled