Human Metabotropic Glutamate Receptor 5 (GRM5) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GRM5
Locus ID	2915
Kit Components	GA101970G1, Metabotropic Glutamate Receptor 5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101970G2, Metabotropic Glutamate Receptor 5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101970G3, Metabotropic Glutamate Receptor 5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000842, NM_001143831
UniProt ID	P41594
Synonyms	GPRC1E; mGlu5; MGLUR5; PPP1R86
Summary	This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]