Human Metabotropic Glutamate Receptor 2 (GRM2) activation kit by CRISPRa

CAT#: GA101967

GRM2 CRISPRa kit - CRISPR gene activation of human glutamate metabotropic receptor 2



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Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol GRM2
Locus ID 2912
Kit Components

GA101967G1, Metabotropic Glutamate Receptor 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101967G2, Metabotropic Glutamate Receptor 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101967G3, Metabotropic Glutamate Receptor 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_000839, NM_001130063, NM_001349116, NM_001349117, NR_146059
UniProt ID Q14416
Synonyms GLUR2; GPRC1B; mGlu2; MGLUR2
Summary L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

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