Human Metabotropic Glutamate Receptor 1 (GRM1) activation kit by CRISPRa

CAT#: GA101966

GRM1 CRISPRa kit - CRISPR gene activation of human glutamate metabotropic receptor 1

Find the corresponding CRISPRi Inhibitor Kit

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Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol GRM1
Locus ID 2911
Kit Components

GA101966G1, Metabotropic Glutamate Receptor 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101966G2, Metabotropic Glutamate Receptor 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101966G3, Metabotropic Glutamate Receptor 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_000838, NM_001114329, NM_001278064, NM_001278065, NM_001278066, NM_001278067
UniProt ID Q13255
Synonyms GPRC1A; GRM1A; mGlu1; MGLUR1; MGLUR1A; SCAR13
Summary This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]


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