Human alpha Glucosidase II (GANAB) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GANAB
Locus ID	23193
Kit Components	GA108112G1, alpha Glucosidase II gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108112G2, alpha Glucosidase II gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108112G3, alpha Glucosidase II gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001278192, NM_001278193, NM_001278194, NM_001329222, NM_001329223, NM_001329224, NM_001329225, NM_014610, NM_198334, NM_198335
UniProt ID	Q14697
Synonyms	G2AN; GIIA; GLUII; PKD3
Summary	This gene encodes the alpha subunit of glucosidase II and a member of the glycosyl hydrolase 31 family of proteins. The heterodimeric enzyme glucosidase II plays a role in protein folding and quality control by cleaving glucose residues from immature glycoproteins in the endoplasmic reticulum. Expression of the encoded protein is elevated in lung tumor tissue and in response to UV irradiation. Mutations in this gene cause autosomal-dominant polycystic kidney and liver disease. [provided by RefSeq, Jul 2016]