Desmocollin 1 (DSC1) (NM_024421) Human Tagged ORF Clone Lentiviral Particle

Specifications

Product Data
Type	Human Tagged ORF Clone Lentiviral Particle
Tag	Myc-DDK
Symbol	Desmocollin 1
Synonyms	CDHF1; DG2/DG3
Mammalian Cell Selection	Puromycin
Vector	pLenti-C-Myc-DDK-P2A-Puro
ACCN	NM_024421
ORF Size	2682 bp
Sequence Data	ORF Nucleotide Sequence (showhide) The ORF insert of this clone is exactly the same as(RC214491).
OTI Disclaimer	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq	NM_024421.1, NP_077739.1
RefSeq Size	4225 bp
RefSeq ORF	2685 bp
Locus ID	1823
UniProt ID	Q08554
Cytogenetics	18q12.1
Protein Families	Transmembrane
MW	96.9 kDa
Gene Summary	The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein. [provided by RefSeq, Nov 2015]