Histone H3 K27M in Gliomas

Rabbit monoclonal antibody anti-H3K27M Histone - Specific marker for glioma

• Monoclonal Antibody : Clone RM192
• Recognizes the mutant form of histone H3 K27M
• No cross reactivity with wild type Histone H3
• H3 K27M is a specific marker for the diagnosis of glioma (more information)

A glioma is a type of tumor that starts in the glial cells of the brain or the spine. Gliomas comprise about 30%of all brain tumors and central nervous system tumors, and 80%of all malignant brain tumors.

 

H3 K27M mutation was originally described in pediatric diffuse intrinsic pontine gliomas (DIPGs), but has been recently recognized to occur also in adult midline diffuse gliomas, as well as midline tumors with other morphologies, including gangliogliomas (GGs), anaplastic GGs, pilocytic astrocytomas (PAs), and posterior fossa ependymomas.