General Info
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-REL (1-619) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | REL |
| Gene ID: | 5966 |
| Uniprot ID: | REL_HUMAN |
| Immunogen Region: | 1-619 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-619 of human REL (NP_002899.1). |
| Immunogen Sequence: | MASGAYNPYIEIIEQPRQRG MRFRYKCEGRSAGSIPGEHS TDNNRTYPSIQIMNYYGKGK VRITLVTKNDPYKPHPHDLV GKDCRDGYYEAEFGQERRPL FFQNLGIRCVKKKEVKEAII TRIKAGINPFNVPEKQLNDI EDCDLNVVRLCFQVFLPDEH GNLTTALPPVVSNPIYDNRA PNTAELRICRVNKNCGSVRG GDEIFLLCDKVQKDDIEVRF VLNDWEAKGIFSQADVHRQ |
Description
| Function | Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. |
| Protein Name | Proto-Oncogene C-Rel |
| Database Links | Reactome: R-HSA-1169091 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Proto-Oncogene C-Rel antibodyAnti-REL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance