Anti-RAB11B antibody (140-220 C-Term)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 IHC-P 1:50-300
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	RAB11B
Gene ID:	9230
Uniprot ID:	RB11B_HUMAN
Immunogen Region:	164-213 aa
Specificity:	Rab 11B Polyclonal Antibody detects endogenous levels of Rab 11B protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human RAB11B at the amino acid range 164-213

Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (Probable). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (Probable).
Protein Name	Ras-Related Protein Rab-11b Gtp-Binding Protein Ypt3
Database Links	Reactome: R-HSA-8854214 Reactome: R-HSA-8873719
Cellular Localisation	Recycling Endosome Membrane Lipid-Anchor Cytoplasmic Side Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle Membrane Phagosome Membrane Recruited To Phagosomes Containing S Aureus
Alternative Antibody Names	Anti-Ras-Related Protein Rab-11b antibody Anti-Gtp-Binding Protein Ypt3 antibody Anti-RAB11B antibody Anti-YPT3 antibody

Information sourced from Uniprot.org

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