Anti-PTPRN2 antibody (180-260 Internal)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 IHC-P 1:50-300 ELISA 2000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	PTPRN2
Gene ID:	5799
Uniprot ID:	PTPR2_HUMAN
Immunogen Region:	206-255 aa
Specificity:	PTP IA-2 Beta Polyclonal Antibody detects endogenous levels of PTP IA-2 Beta protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human PTPRN2 at the amino acid range 206-255

Post Translational Modifications	Subject to proteolytic cleavage at multiple sites.
Function	Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Required to maintain normal levels of renin expression and renin release. May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization. Has phosphatidylinositol phosphatase activity.the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate. Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis.upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments.
Protein Name	Receptor-Type Tyrosine-Protein Phosphatase N2 R-Ptp-N2 Islet Cell Autoantigen-Related Protein Iar Icaar Phogrin Cleaved Into - Ia-2beta60
Database Links	Reactome: R-HSA-6798695
Cellular Localisation	Cytoplasmic Vesicle Secretory Vesicle Membrane Single-Pass Type I Membrane Protein Secretory Vesicle Synaptic Vesicle Membrane Predominantly Found On Dense-Core Secretory Granules Sorting To Secretory Granules In Part Is Dependent Of The N-Terminal Propeptide Domain Of The Precursor And Its Interaction With Cpe Transiently Found At The Cell Membrane When Secretory Vesicles Fuse With The Cell Membrane To Release Their Cargo Is Then Endocytosed And Recycled To Secretory Vesicles Involving Clathrin-Dependent Ap2-Mediated Endocytosis Recycled Via Stx6- But Not Tttgn1/Tgn38-Containing Compartments Ia-2beta60: Cytoplasmic Vesicle
Alternative Antibody Names	Anti-Receptor-Type Tyrosine-Protein Phosphatase N2 antibody Anti-R-Ptp-N2 antibody Anti-Islet Cell Autoantigen-Related Protein antibody Anti-Iar antibody Anti-Icaar antibody Anti-Phogrin Cleaved Into - Ia-2beta60 antibody Anti-PTPRN2 antibody Anti-KIAA0387 antibody

Information sourced from Uniprot.org

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