General Info
| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Phospho-Alpha-crystallin B chain-crystallin-Ser59 (31-80 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | CRYAB |
| Gene ID: | 1410 |
| Uniprot ID: | CRYAB_HUMAN |
| Immunogen Region: | 31-80 aa |
| Specificity: | Phospho-Crystallin-Alpha B (S59) Polyclonal Antibody detects endogenous levels of Crystallin-Alpha B protein only when phosphorylated at S59. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CRYAB/Crystallin-alpha-B around the phosphorylation site of Ser59 at the amino acid range 31-80 |
Description
| Function | May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome. |
| Protein Name | Alpha-Crystallin B ChainAlpha(B-CrystallinHeat Shock Protein Beta-5Hspb5Renal Carcinoma Antigen Ny-Ren-27Rosenthal Fiber Component |
| Database Links | Reactome: R-HSA-3371571 |
| Cellular Localisation | CytoplasmNucleusSecretedLysosomeTranslocates To The Nucleus During Heat Shock And Resides In Sub-Nuclear Structures Known As Sc35 Speckles Or Nuclear Splicing SpecklesLocalizes At The Z-Bands And The Intercalated Disk In CardiomyocytesCan Be SecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Antibody Names | Anti-Alpha-Crystallin B Chain antibodyAnti-Alpha(B-Crystallin antibodyAnti-Heat Shock Protein Beta-5 antibodyAnti-Hspb5 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-27 antibodyAnti-Rosenthal Fiber Component antibodyAnti-CRYAB antibodyAnti-CRYA2 antibodyAnti-HSPB5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance