Anti-NPAS4 antibody (580-660 C-Term)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	IHC 1:100-1:300 ELISA 1:20000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	NPAS4
Gene ID:	266743
Uniprot ID:	NPAS4_HUMAN
Immunogen Region:	603-652
Specificity:	NPAS4 Polyclonal Antibody detects endogenous levels of NPAS4 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from human NPAS4. AA range:603-652

Tissue Specificity	Brain.
Post Translational Modifications	Ubiquitinated, leading to degradation by the proteosome.
Function	Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience. In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons. In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits. The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior. Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2. Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1. Can activate the CME (CNS midline enhancer) element.
Protein Name	Neuronal Pas Domain-Containing Protein 4 Neuronal Pas4 Class E Basic Helix-Loop-Helix Protein 79 Bhlhe79 Hlh-Pas Transcription Factor Nxf Pas Domain-Containing Protein 10
Database Links	Reactome: R-HSA-9768778 Reactome: R-HSA-9768919
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Neuronal Pas Domain-Containing Protein 4 antibody Anti-Neuronal Pas4 antibody Anti-Class E Basic Helix-Loop-Helix Protein 79 antibody Anti-Bhlhe79 antibody Anti-Hlh-Pas Transcription Factor Nxf antibody Anti-Pas Domain-Containing Protein 10 antibody Anti-NPAS4 antibody Anti-BHLHE79 antibody Anti-NXF antibody Anti-PASD10 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance