General Info
| Host: | Rabbit |
| Applications: | IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Heart-and neural crest derivatives-expressed protein 1 (141-190 aa) is suitable for use in Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | HAND1 |
| Gene ID: | 9421 |
| Uniprot ID: | HAND1_HUMAN |
| Immunogen Region: | 141-190 aa |
| Specificity: | HAND1 Polyclonal Antibody detects endogenous levels of HAND1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human HAND1 at the amino acid range 141-190 |
Description
| Post Translational Modifications | Phosphorylation by PLK4 disrupts the interaction with MDFIC and leads to translocation into the nucleoplasm, allowing dimerization and transcription factor activity. |
| Function | Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box). Acts as a transcriptional repressor of SOX15. In the adult, could be required for ongoing expression of cardiac-specific genes. |
| Protein Name | Heart- And Neural Crest Derivatives-Expressed Protein 1Class A Basic Helix-Loop-Helix Protein 27Bhlha27Extraembryonic Tissues - Heart - Autonomic Nervous System And Neural Crest Derivatives-Expressed Protein 1Ehand |
| Database Links | Reactome: R-HSA-9733709 |
| Cellular Localisation | NucleusNucleoplasmNucleolusInteraction With Mdfic Sequesters It Into The NucleolusPreventing The Transcription Factor ActivityPhosphorylation By Plk4 Disrupts The Interaction With Mdfic And Releases It From The NucleolusLeading To Transcription Factor Activity |
| Alternative Antibody Names | Anti-Heart- And Neural Crest Derivatives-Expressed Protein 1 antibodyAnti-Class A Basic Helix-Loop-Helix Protein 27 antibodyAnti-Bhlha27 antibodyAnti-Extraembryonic Tissues - Heart - Autonomic Nervous System And Neural Crest Derivatives-Expressed Protein 1 antibodyAnti-Ehand antibodyAnti-HAND1 antibodyAnti-BHLHA27 antibodyAnti-EHAND antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance