General Info
| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Homeobox Protein Cut-Like 1/Protein CASP and Homeobox Protein Cut-Like 1/Protein CASP (10-59 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | CUX1CUX1 |
| Gene ID: | 15231523 |
| Uniprot ID: | CASP_HUMANCUX1_HUMAN |
| Immunogen Region: | 10-59 aa |
| Specificity: | CUX1 Polyclonal Antibody detects endogenous levels of CUX1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CUTL1 at the amino acid range 10-59 |
Description
| Function | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor.binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer.may require the basic helix-loop-helix protein TCF4 as a coactivator. CDP/Cux p110: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. |
| Protein Name | Homeobox Protein Cut-Like 1Ccaat Displacement ProteinCdpCdp/Cux P200Homeobox Protein Cux-1 Cleaved Into - Cdp/Cux P110 |
| Database Links | Reactome: R-HSA-6811438Reactome: R-HSA-1839117Reactome: R-HSA-5655302 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Cut-Like 1 antibodyAnti-Ccaat Displacement Protein antibodyAnti-Cdp antibodyAnti-Cdp/Cux P200 antibodyAnti-Homeobox Protein Cux-1 Cleaved Into - Cdp/Cux P110 antibodyAnti-CUX1 antibodyAnti-CUTL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance