General Info
| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Prostaglandin D2 receptor 2 (161-210 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC-P 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | PTGDR2 |
| Gene ID: | 11251 |
| Uniprot ID: | PD2R2_HUMAN |
| Immunogen Region: | 161-210 aa |
| Specificity: | CD294 Polyclonal Antibody detects endogenous levels of CD294 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human PTGDR2 at the amino acid range 161-210 |
Description
| Post Translational Modifications | Phosphorylated. |
| Function | Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. |
| Protein Name | Prostaglandin D2 Receptor 2Chemoattractant Receptor-Homologous Molecule Expressed On Th2 CellsG-Protein Coupled Receptor 44Cd Antigen Cd294 |
| Database Links | Reactome: R-HSA-391908Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalized Receptors Colocalized With Rab11a |
| Alternative Antibody Names | Anti-Prostaglandin D2 Receptor 2 antibodyAnti-Chemoattractant Receptor-Homologous Molecule Expressed On Th2 Cells antibodyAnti-G-Protein Coupled Receptor 44 antibodyAnti-Cd Antigen Cd294 antibodyAnti-PTGDR2 antibodyAnti-CRTH2 antibodyAnti-DL1R antibodyAnti-GPR44 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance