General Info
| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Solute carrier family 22 member 17 (Internal) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC-P 1:100-300ELISA 1:5000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | SLC22A17 |
| Gene ID: | 51310 |
| Uniprot ID: | S22AH_HUMAN |
| Immunogen Region: | Internal |
| Specificity: | BOCT Polyclonal Antibody detects endogenous levels of BOCT protein. |
| Immunogen: | Synthesized peptide derived from the Internal region of human BOCT. |
Description
| Function | Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. |
| Protein Name | Solute Carrier Family 22 Member 1724p3 Receptor24p3rBrain-Type Organic Cation TransporterLipocalin-2 ReceptorNeutrophil Gelatinase-Associated Lipocalin ReceptorNgalr |
| Database Links | Reactome: R-HSA-917937 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinVacuole MembraneUpon Lcn2-BindingIt Is Internalized |
| Alternative Antibody Names | Anti-Solute Carrier Family 22 Member 17 antibodyAnti-24p3 Receptor antibodyAnti-24p3r antibodyAnti-Brain-Type Organic Cation Transporter antibodyAnti-Lipocalin-2 Receptor antibodyAnti-Neutrophil Gelatinase-Associated Lipocalin Receptor antibodyAnti-Ngalr antibodyAnti-SLC22A17 antibodyAnti-BOCT antibodyAnti-BOIT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance