Voriconazole [137234-62-9]

Cat# HY-76200-100mg

Size : 100mg

Brand : MedChemExpress

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Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes.

For research use only. We do not sell to patients.

Voriconazole Chemical Structure

CAS No. : 137234-62-9

*

This product is a controlled substance and not for sale in your territory.

  • Transl Res. 2022 Apr 20;S1931-5244(22)00073-1.  [Abstract]
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  • Infect Drug Resist. 2022: 7459-7473.
  • J Mycol Med. 9 November 2021, 101227.
  • Med Mycol. 2018 Jun 1;56(4):452-457.  [Abstract]
  • Laryngoscope Investig Otolaryngol. 28 October 2022.
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes.

In Vitro

Voriconazole has great activity against S. apiospermum and C. neoformans with the MICs of 0.5 μg/mL and 0.125-0.25 μg/mL, respectively.
Voriconazole inhibits the cytochrome P450 (CYP)-dependent enzyme 14-alpha-sterol demethylase, thereby disrupting the cell membrane and halting fungal growth.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Voriconazole (5-20 mg/kg; p.o. for 21 days) prolongs survival in a dose-dependent fashion. Voriconazole (40 mg/kg/day) decreases the fungal burden in the lungs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male specific-pathogen-free BALB/cByJ mice
Dosage: 1, 5, 20 mg/kg/day
Administration: P.o. once daily for 21 days
Result: Improved survival in a dose-response fashion, with median survival times (MSTs) of 21, 28, and 35 days with doses of 1, 5, and 20 mg/kg, respectively.

349.31

C16H14F3N5O

137234-62-9

Solid

White to off-white

O[C@@]([C@@H](C)C1=NC=NC=C1F)(CN2N=CN=C2)C(C(F)=C3)=CC=C3F

Room temperature in continental US; may vary elsewhere.

In Vitro: 

DMSO : ≥ 50 mg/mL (143.14 mM)

H2O : 0.17 mg/mL (0.49 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8628 mL 14.3139 mL 28.6279 mL
5 mM 0.5726 mL 2.8628 mL 5.7256 mL
10 mM 0.2863 mL 1.4314 mL 2.8628 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.16 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.16 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.16 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
  • [1]. Nickie D Greer, et al. Voriconazole: the newest triazole antifungal agent.Proc (Bayl Univ Med Cent). 2003 Apr;16(2):241-8.  [Content Brief]

  • [1]. Nickie D Greer, et al. Voriconazole: the newest triazole antifungal agent.Proc (Bayl Univ Med Cent). 2003 Apr;16(2):241-8.

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  • Anti-infection
  • Fungal Bacterial
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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