Voriconazole [137234-62-9]
Cat# HY-76200-100mg
Size : 100mg
Brand : MedChemExpress
Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes.
For research use only. We do not sell to patients.
Voriconazole Chemical Structure
CAS No. : 137234-62-9
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This product is a controlled substance and not for sale in your territory.
- •Transl Res. 2022 Apr 20;S1931-5244(22)00073-1. [Abstract]
- •Front Cell Infect Microbiol. 2020 Jun 26;10:320. [Abstract]
- •Infect Drug Resist. 2022: 7459-7473.
- •J Mycol Med. 9 November 2021, 101227.
- •Med Mycol. 2018 Jun 1;56(4):452-457. [Abstract]
- •Laryngoscope Investig Otolaryngol. 28 October 2022.
Biological Activity
Purity & Documentation
References
Customer Review
Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes. | ||||||||||||||||
In Vitro | Voriconazole has great activity against S. apiospermum and C. neoformans with the MICs of 0.5 μg/mL and 0.125-0.25 μg/mL, respectively. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||||||||
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In Vivo | Voriconazole (5-20 mg/kg; p.o. for 21 days) prolongs survival in a dose-dependent fashion. Voriconazole (40 mg/kg/day) decreases the fungal burden in the lungs. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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349.31 | ||||||||||||||||
C16H14F3N5O | ||||||||||||||||
137234-62-9 | ||||||||||||||||
Solid | ||||||||||||||||
White to off-white | ||||||||||||||||
O[C@@]([C@@H](C)C1=NC=NC=C1F)(CN2N=CN=C2)C(C(F)=C3)=CC=C3F | ||||||||||||||||
Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
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In Vitro: DMSO : ≥ 50 mg/mL (143.14 mM) H2O : 0.17 mg/mL (0.49 mM; Need ultrasonic) *"≥" means soluble, but saturation unknown. Preparing Stock Solutions
*Please refer to the solubility information to select the appropriate solvent. In Vivo:
*All of the co-solvents are available by MedChemExpress (MCE). | ||||||||||||||||
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[1]. Nickie D Greer, et al. Voriconazole: the newest triazole antifungal agent.Proc (Bayl Univ Med Cent). 2003 Apr;16(2):241-8.
- Anti-infection
- Fungal Bacterial
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.