- More Files
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using TSC2 polyclonal antibody (Cat # PAB18231).
Peptide "+" means "peptide blocking".
- Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TSC2.
Immunogen
A synthetic peptide corresponding to human TSC2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to TSC2.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using TSC2 polyclonal antibody (Cat # PAB18231).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
- Gene Info — TSC2
Entrez GeneID
7249Protein Accession#
P49815Gene Name
TSC2
Gene Alias
FLJ43106, LAM, TSC4
Gene Description
tuberous sclerosis 2
Gene Ontology
HyperlinkGene Summary
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
tuberin
- Interactome
- Pathway
- Disease
- Publication Reference
- Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2.
Finlay GA, York B, Karas RH, Fanburg BL, Zhang H, Kwiatkowski DJ, Noonan DJ.
The Journal of Biological Chemistry 2004 May; 279(22):23114.
Application：WB, Human, HEK 293 cells.
- Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis.
Aicher LD, Campbell JS, Yeung RS.
The Journal of Biological Chemistry 2001 Jun; 276(24):21017.
Application：IP, WB-Ce, WB-Tr, Human, Mouse, Rat, COS-1, HeLa, LEF8, NIH/3T3 cells, Rat-derived embryonic fibroblasts.
- Similarities and differences in the subcellular localization of hamartin and tuberin in the kidney.
Murthy V, Haddad LA, Smith N, Pinney D, Tyszkowski R, Brown D, Ramesh V.
American Journal of Physiology. Renal Physiology 2000 May; 278(5):F737.
- Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2.