keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tauroursodeoxycholate sodium [35807-85-3]
Cat# T6993-200mg
Size : 200mg
Brand : TargetMol
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Tauroursodeoxycholate sodium
Catalog No. T6993 CAS 35807-85-3
Synonyms: Sodium tauroursodeoxycholate, Tauroursodeoxycholic acid sodium salt, TUDC, Sodium Tauroursodeoxycholate (TUDC)
Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
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Tauroursodeoxycholate sodium, CAS 35807-85-3
| Description | Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis. |
| In vivo | In phalloidin-induced cholestasis rats, Tauroursodeoxycholate (360 μmol/kg, i.v.) significantly suppresses the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations. [2] |
| Cell Research | Cell lines: Mz-ChA-1 cells. Concentrations: ~200 μM. Method: After trypsinization,Mz-ChA-1 cells are suspended in CCM at 5×104 cells/mL,and 200 μL of the cell suspension is seeded into 96-well plates.After an initial incubation step of 4 h at 37°C in a 5% CO2 incubator,the cells are incubated at 37°C with TUDCA (0.2–200 μM).After incubation for 24–96 h,[3H]thymidine is put into each well at 5.0 μCi/mL and incubated for additional 4 h.[3H]thymidine incorporation is measured by a scintillation counter. |
| Animal Research | Animal Models: Phalloidin-induced cholestasis ratsFormulation & . Dosages: Saline; 360 μMol/kg. Administration: intravenous injection |
| Synonyms | Sodium tauroursodeoxycholate, Tauroursodeoxycholic acid sodium salt, TUDC, Sodium Tauroursodeoxycholate (TUDC) |
| Molecular Weight | 521.69 |
| Formula | C26H44NNaO6S |
| CAS No. | 35807-85-3 |
Storage
Solubility Information
Ethanol: 10 mg/mL(19.2 mM)
DMSO: 55 mg/mL (105.43 mM)
H2O: 92 mg/mL (176.3 mM)
References and Literature
1. Milkiewicz P, et al. J Hepatol. 2001, 34(2), 184-191. 2. Ishizaki K, et al. Eur J Pharmacol. 2001, 421(1), 55-60. 3. Alpini G, et al. Am J Physiol Gastrointest Liver Physiol. 2004, 286(6), G973-982. 4. Sommerfeld A, et al. Cell Physiol Biochem. 2015, 36(3), 866-883. 5. Luo R, Li L, Liu X, et al. Mesenchymal stem cells alleviate palmitic acid-induced endothelial-to-mesenchymal transition by suppressing endoplasmic reticulum stress[J]. American Journal of Physiology-Endocrinology and Metabolism. 2020, 319(6): E961-E980. 6. Luo R, Li L, Liu X, et al. Mesenchymal stem cells alleviate palmitic acid induced endothelial to mesenchymal transition by suppressing endoplasmic reticulum stress[J]. American Journal of Physiology-Endocrinology and Metabolism. 2020 7. Che J, Lv H, Yang J, et al. Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2α/ATF4/CHOP pathway in vitro[J]. Cellular Signalling. 2021: 110024.
Citations
1. Che J, Lv H, Yang J, et al. Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2α/ATF4/CHOP pathway in vitro. Cellular Signalling. 2021 Aug;84:110024. doi: 10.1016/j.cellsig.2021.110024. Epub 2021 Apr 24. 2. Luo R, Li L, Liu X, et al. Mesenchymal stem cells alleviate palmitic acid induced endothelial to mesenchymal transition by suppressing endoplasmic reticulum stress. American Journal of Physiology-Endocrinology and Metabolism. 2020