Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sulfosuccinimidyl oleate sodium [1212012-37-7]
Cat# T13036L-5mg
Size : 5mg
Brand : TargetMol
Sulfosuccinimidyl oleate sodium
Catalog No. T13036L CAS 1212012-37-7
Synonyms: Sulfo-N-succinimidyl oleate sodium
Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long-chain fatty acid that inhibits the transport of fatty acids to cells. Sulfosuccinimidyl oleate sodium is an effective, irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to CD36 receptors on the surface of microglia.
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Sulfosuccinimidyl oleate sodium, CAS 1212012-37-7
Description | Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long-chain fatty acid that inhibits the transport of fatty acids to cells. Sulfosuccinimidyl oleate sodium is an effective, irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to CD36 receptors on the surface of microglia. |
In vitro | Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours)[1]. |
In vivo | In male BALB/cABom mice with pMCAo model, Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls. In addition, Sulfosuccinimidyl oleate(50 mg/kg) is suitable to see a beneficial effect after stroke[1]. |
Synonyms | Sulfo-N-succinimidyl oleate sodium |
Molecular Weight | 481.58 |
Formula | C22H36NNaO7S |
CAS No. | 1212012-37-7 |
Storage
Solubility Information
DMSO: 60 mg/mL (124.59 mM), Sonication is recommended.
References and Literature
1. Dhungana H, et al. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. J Neuroinflammation. 2017 Dec 4;14(1):237. 2. Drahota Z, et al. Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain. Biochem Biophys Res Commun. 2010 Jan 15;391(3):1348-51.