Description

StemBeads® GDNF is a patented growth factor supplement that offers a novel way to culture cells with native Glial Derived Neurotrophic Factor more efficiently, with greater control and fewer medium changes. GDNF is key for supporting neural progenitor cells (NPCs) and neuronal differentiation. StemBeads® GDNF are microbeads composed of an FDA approved, biodegradable PLGA polymer that is loaded with native, non-mutant recombinant human GDNF and release the encapsulated protein at a constant rate. Controlled delivery and stable levels overcome the 45-minute half-life (Figure above) of GDNF and improve cell cultures while saving researchers valuable time and resources.

StemBeads® GDNF has been tested in multiple neuronal base media, including neural progenitor expansion media (NPEM), with enhanced cellular profiles. In these cases, StemBeads® GDNF were used with and without StemBeads® BDNF.

StemBeads GDNF Product Information Sheet
Frequently Asked Questions
SDS – StemBeads^®  GDNF

Sustained Release Protein Cell Culture

StemBeads are a revolutionary controlled-release growth factor technology. The StemBeads product is currently used for improved cell culture in more than 100 scientific laboratories globally. StemBeads technology encapsulates a growth factor in a PLGA hydrogel that stabilizes the protein and releases it steadily over several days. With growth factor levels stabilized, spontaneous differentiation is reduced, pluripotency is increased, and feeding schedules are reduced to only 2-3 times per week.

StemBeads are added to your medium to achieve a desired growth factor release, sustained over several days. Following, the beads are washed from the culture, the medium is replaced, and the process repeated as required.