Specifications

Product Data
Clone Name	H202-529.4.1.4
Applications	FC
Recommended Dilution	Flow Cytometry: Neat - 1/50; Use 10 µl of the suggested working dilution to label 1x10e6 cells in 100 µl.
Reactivities	Mouse
Host	Rat
Isotype	IgG1
Clonality	Monoclonal
Immunogen	Thymic epithelial cells from mouse
Specificity	This antibody recognises CD98 (also known as 4F2 and SLC3A2), a type II transmembrane glycoprotein which associates with members of the L-type amino transporter family to form a heterodimeric complex.
Formulation	Phosphate buffered saline pH 7.4 containing 0.09% Sodium Azide (NaN3) State: Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage	Store the antibody undiluted at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
Stability	Shelf life: one year from despatch.
Gene Name	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Database Link	Entrez Gene 17254 Mouse UniProt ID P10852
Background	CD98 constitutes the heavy chain of the complex and is required for the surface expression and basolateral localization of the amino acid transporter complex in polarized epithelial cells. The CD98 heavy chain also interacts with beta 1 integrins and regulates their activation through the cytoplasmic domains and transmembrane regions. Studies suggest that overexpression of CD98 may contribute to cell growth and survival by regulating integrin signalling, and therefore may play an important role in tumorigenesis.
Synonyms	4F2hc, MDU1
Reference Data