SIRT4 Antibody - N-terminal region : Biotin
Cat# ARP32452_P050-Biotin
Size : 100ul
Brand : Aviva Systems Biology
Contact local distributor :
Phone : +1 850 650 7790
SIRT4 Antibody - N-terminal region : Biotin (ARP32452_P050-Biotin)
| Datasheets/Manuals | Printable datasheet for anti-SIRT4 (ARP32452_P050-Biotin) antibody |
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| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Pig, Rabbit, Sheep, Zebrafish |
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| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Conjugation | Biotin |
| Application | WB |
| Reconstitution and Storage | All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human SIRT4 |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100% |
| Peptide Sequence | Synthetic peptide located within the following region: ASPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYAR |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-SIRT4 (ARP32452_P050-Biotin) antibody is Catalog # AAP32452 (Previous Catalog # AAPP03448) |
| Reference | Ahuja,N., (2007) J. Biol. Chem. 282 (46), 33583-33592 |
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| Gene Symbol | SIRT4 |
| Gene Full Name | Sirtuin 4 |
| Alias Symbols | SIR2L4 |
| NCBI Gene Id | 23409 |
| Protein Name | NAD-dependent protein deacetylase sirtuin-4 |
| Description of Target | SIRT4 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT4 is included in class IV of the sirtuin family. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. |
| Uniprot ID | Q9Y6E7 |
| Protein Accession # | NP_036372 |
| Nucleotide Accession # | NM_012240 |
| Protein Size (# AA) | 314 |
| Molecular Weight | 35kDa |
| Protein Interactions | SKP2; Glud1; UBC; SIRT3; IDE; SLC25A6; SLC25A5; |
