Rat CRN (Corin) Sandwich ELISA Kit Ready-To-Use

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	Corin
Gene ID:	289596
Uniprot ID:	CORIN_RAT
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Specifically expressed in heart. Also detected in kidney, aorta, brain and testis. In kidney, present in epithelial cells, with segmental expression in the proximal tubule, thick ascending limb, connecting tubule, and throughout the collecting duct (at protein level).
Post Translational Modifications	N-glycosylated.required for processing and activation. Activated through proteolytic processing by a trypsin-like protease.cleaved into a N-terminal propeptide and an activated corin protease fragment. Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1 (Probable). A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment (Probable).
Function	Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.
Protein Name	Atrial Natriuretic Peptide-Converting Enzyme Corin Pro-Anp-Converting Enzyme Cleaved Into - Atrial Natriuretic Peptide-Converting Enzyme - N-Terminal Propeptide - Atrial Natriuretic Peptide-Converting Enzyme - Activated Protease Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 180 Kda Soluble Fragment
Database Links	Reactome: R-RNO-5578768
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein Cytoplasmic Vesicle Atrial Natriuretic Peptide-Converting Enzyme 180 Kda Soluble Fragment: Secreted Soluble Form Produced Following Cleavage By Adam10
Alternative ELISA Names	Atrial Natriuretic Peptide-Converting Enzyme ELISA kit Corin ELISA kit Pro-Anp-Converting Enzyme Cleaved Into - Atrial Natriuretic Peptide-Converting Enzyme - N-Terminal Propeptide - Atrial Natriuretic Peptide-Converting Enzyme - Activated Protease Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 180 Kda Soluble Fragment ELISA kit Corin ELISA kit
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Information sourced from Uniprot.org

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