Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pyridostatin TFA [1472611-44-1]
Cat# T4470-50mg
Size : 50mg
Brand : TargetMol
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Pyridostatin TFA
Catalog No. T4470 CAS 1472611-44-1
Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.
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Pyridostatin TFA, CAS 1472611-44-1
| Description | Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2. |
| Targets&IC50 | G-quadruplexe(Cell-free assay):490 nM(Kd) |
| In vitro | Pyridostatin decreases the proliferation of MRC-5–SV40 cells and various cancer cell lines, and induces cell-cycle arrest by DNA-damage checkpoint activation. Pyridostatin also reduces SRC-dependent cell motility in MDA-MB-231 cells by interacting with G-quadruplex motifs in SRC.Pyridostatin decreases EBNA1 synthesis via inhibition of G-quadruplexes. |
| Cell Research | Cell lines: MRC-5–SV40 cells and various cancer cell linesConcentrations: 10 μMIncubation Time: 48 hMethod: Cells are plated at equal confluence and are left either untreated or were treated with 2 μM pyridostatin continually during the indicated time before harvesting the cells. Cells from individual plates are trypsinized and counted in a Coulter counter. Graphs represent the total cell numbers at each time interval, and the error bars represent the s.e.m. Data represent three independent experiments. |
| Molecular Weight | 938.71 |
| Formula | C37H35F9N8O11 |
| CAS No. | 1472611-44-1 |
Storage
Solubility Information
DMSO: 90 mg/mL (95.88 mM)
References and Literature
1. Koirala D,etal.A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.Nat Chem. 2011 Aug 28;3(10):782-7. 2. Rodriguez R,etal. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.Nat Chem Biol. 2012 Feb 5;8(3):301-10. 3. Murat P,etal.G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation.Nat Chem Biol. 2014 May;10(5):358-64.