ProteinFind® Anti-Bax Mouse Monoclonal Antibody

Bax (Bcl-2-associated X protein) is a member of the Bcl-2 family. This protein can promote apoptosis in the form of a dimer with the Bcl-2 family.^[1] When the cell is not stimulated by apoptotic signals, Bax is located in the cytoplasm. When cells are stimulated by apoptosis signals, such as staurosporine or DNA damage, Bax undergoes conformational changes to form heterodimers and then transfer from the cytoplasm to the outer mitochondrial membrane, opening the voltage-dependent anion channel (VDAC), changing the membrane potential, and releasing various pro-apoptotic factors, such as Cytochrome C, SMAC/Diablo, etc, which affect cell apoptosis.^[2]

Storage

PBS (pH 7.4), 0.02% Sodium Azide, 50% Glycerol; at -20℃ for two years, avoid repeated freezing and thawing.

Shipping

Dry ice (-70℃)

[1]. Misao J, Hayakawa Y, Ohno M, Kato S, Fujiwara T, Fujiwara H. Expression of bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction[J]. Circulation. 1996, 94 (7): 1506.

[2]. Valentijn AJ, Upton JP, Gilmore AP. Analysis of endogenous Bax complexes during apoptosis using blue native PAGE: implications for Bax activation and oligomerization[J]. Biochemical Journal. 2008, 412 (2): 347-57.