PAK1/PAK2/PAK3 polyclonal antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical analysis of paraffin-embedded human brain tissue using PAK1/PAK2/PAK3 polyclonal antibody (Cat # PAB18203).
Peptide "+" means "peptide blocking".

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

5058

Gene Name

PAK1

Gene Alias

MGC130000, MGC130001, PAKalpha

Gene Description

p21 protein (Cdc42/Rac)-activated kinase 1

Omim ID

602590

Gene Ontology

Hyperlink

Gene Summary

PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternativelt spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

STE20 homolog, yeast|p21-activated kinase 1|p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)|p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)

Entrez GeneID

5062

Gene Name

PAK2

Gene Alias

PAK65, PAKgamma

Gene Description

p21 protein (Cdc42/Rac)-activated kinase 2

Omim ID

605022

Gene Ontology

Hyperlink

Gene Summary

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq

Other Designations

S6/H4 kinase|p21 (CDKN1A)-activated kinase 2|p21-activated kinase 2

Entrez GeneID

5063

Gene Name

PAK3

Gene Alias

CDKN1A, MRX30, MRX47, OPHN3, PAK3beta, bPAK, hPAK3

Gene Description

p21 protein (Cdc42/Rac)-activated kinase 3

Omim ID

300142 300558

Gene Ontology

Hyperlink

Gene Summary

PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq

Other Designations

OTTHUMP00000023855|OTTHUMP00000062894|beta-PAK|oligophrenin-3|p21 (CDKN1A)-activated kinase 3|p21-activated kinase 3|p21-activated kinase-3|serine/threonine-protein kinase PAK 3