p53 (TP53) Mouse Monoclonal Antibody [Clone ID: OTI5E2]
CAT#: TA502870
TP53 mouse monoclonal antibody, clone OTI5E2 (formerly 5E2)
Size: 30 ul
Formulation: Carrier-Free
Conjugation: Biotin HRP
Specifications
| Product Data | |
| Clone Name | OTI5E2 |
| Applications | FC, IF, IHC, WB |
| Recommended Dilution | WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100 |
| Reactivities | Human, Monkey, Mouse |
| Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human TP53 (NP_000537) produced in HEK293T cell. |
| Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Predicted Protein Size | 43.5 kDa |
| Gene Name | tumor protein p53 |
| Database Link | |
| Background | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq] |
| Synonyms | BCC7; LFS1; P53; TRP53 |
| Reference Data | |
| Protein Families | Druggable Genome, Stem cell - Pluripotency, Transcription Factors |
| Protein Pathways | Amyotrophic lateral sclerosis (ALS), Apoptosis, Basal cell carcinoma, Bladder cancer, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, Glioma, Huntington's disease, MAPK signaling pathway, Melanoma, Neurotrophin signaling pathway, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer, Thyroid cancer, Wnt signaling pathway |
Documents
| Product Manuals |
| FAQs |
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| SDS |
Resources
| Antibody Resources |
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Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| CF502870 | Carrier-free (BSA/glycerol-free) TP53 mouse monoclonal antibody, clone OTI5E2 (formerly 5E2) | 600,00 EUR | |
| TA502870AM | TP53 mouse monoclonal antibody, clone OTI5E2 (formerly 5E2), Biotinylated | 509,00 EUR | |
| TA502870BM | TP53 mouse monoclonal antibody, clone OTI5E2 (formerly 5E2), HRP conjugated | 509,00 EUR | |
| TA502870S | TP53 mouse monoclonal antibody, clone OTI5E2 (formerly 5E2) | 200,00 EUR |