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> NPC 15437 dihydrochloride [136449-85-9]

NPC 15437 dihydrochloride [136449-85-9]

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Cat# VD-IS-0074-50mg

Size : 50mg

Brand : VDM Biochemicals

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Phone : +1 850 650 7790

Product Specification

  • Appearance
    :

    Light yellow to white powder

  • CAS Number
    :

    136449-85-9

  • Cat.number
    :

    VD-IS-0074

  • Formula
    :

    C25H50N4O2.2HCl

  • MW
    :

    511.61

  • Purity
    :

    >98%

  • Solubility
    :

    Soluble to 100 mM in Water

  • Storage
    :

    +4°C.

  • Synonyms
    :

    (2S)-2,6-Diamino-N-[[1-(1-oxotridecyl)- 2-piperidinyl]methyl]hexanamide dihydrochloride

  • Size
    :

    10mg, 50mg

SKU: VD-IS-0074 Categories: Cancer, Intracellular Signaling

Description

NPC 15437 dihydrochloride (CAS 136449-85-9) is a highly selective, competitive and reversible inhibitor of protein kinase C (IC50 = 19 mM); interacts at the regulatory domain of the enzyme. May modulate P-glycoprotein in tumor cells in vitro via inhibiton of PKC. Centrally active following systemic administration in vivo.

1. Sullivan et al (1992) Mol.Pharmacol. 41 38.
2. Mathis et al (1992)  Eur.J.Pharmacol. 220 107.
3. Sha et al (1996) Invest.New Drugs 13 285.