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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Application

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue using MYOM1 polyclonal antibody (Cat # PAB17778).
Peptide "+" means "with peptide blocking".

  • Specification

    Product Description

    Rabbit polyclonal antibody raised against synthetic peptide of MYOM1.

    Immunogen

    A synthetic peptide corresponding to internal of human MYOM1.

    Host

    Rabbit

    Reactivity

    Human

    Specificity

    This antibody detects endogenous levels of total MYOM1 protein.

    Form

    Liquid

    Recommend Usage

    Immunohistochemistry (1:50-1:100)
    ELISA (1:40000)
    The optimal working dilution should be determined by the end user.

    Storage Buffer

    In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)

    Storage Instruction

    Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.

    Note

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

  • Applications

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

    Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue using MYOM1 polyclonal antibody (Cat # PAB17778).
    Peptide "+" means "with peptide blocking".

    Enzyme-linked Immunoabsorbent Assay

  • Gene Info — MYOM1

    Entrez GeneID

    8736

    Protein Accession#

    P52179

    Gene Name

    MYOM1

    Gene Alias

    MGC134946, MGC134947, SKELEMIN

    Gene Description

    myomesin 1, 185kDa

    Omim ID

    603508

    Gene Ontology

    Hyperlink

    Gene Summary

    The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq

    Other Designations

    190 kDa connectin-associated protein|190 kDa titin-associated protein|EH-myomesin|myomesin (M-protein) 1 (190kD)|myomesin 1|myomesin 1 (skelemin) (185kD)|myomesin 1 (skelemin) 185kDa

  • Interactome
  • Disease