- More Files
- Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MYOM1.
Immunogen
A synthetic peptide corresponding to internal of human MYOM1.
Host
Rabbit
Reactivity
Human
Specificity
This antibody detects endogenous levels of total MYOM1 protein.
Form
Liquid
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue using MYOM1 polyclonal antibody (Cat # PAB17778).
Peptide "+" means "with peptide blocking".Enzyme-linked Immunoabsorbent Assay
- Gene Info — MYOM1
Entrez GeneID
8736Protein Accession#
P52179Gene Name
MYOM1
Gene Alias
MGC134946, MGC134947, SKELEMIN
Gene Description
myomesin 1, 185kDa
Omim ID
603508Gene Ontology
HyperlinkGene Summary
The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
190 kDa connectin-associated protein|190 kDa titin-associated protein|EH-myomesin|myomesin (M-protein) 1 (190kD)|myomesin 1|myomesin 1 (skelemin) (185kD)|myomesin 1 (skelemin) 185kDa
- Interactome
- Disease