Mouse OPTN (Optineurin) Sandwich ELISA Kit Ready-To-Use

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	Optn
Gene ID:	71648
Uniprot ID:	OPTN_MOUSE
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity	In eye, it is expressed in anterior segment, retina, and optic nerve blood vessels (at protein level). Highly expressed in adult liver, heart and testis.
Post Translational Modifications	Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection.
Function	Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation. In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR).regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family.targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.
Protein Name	Optineurin
Database Links	Reactome: R-MMU-2565942 Reactome: -MMU-5357905 Reactome: -MMU-5357956 Reactome: -MMU-8854214
Cellular Localisation	Cytoplasm Perinuclear Region Golgi Apparatus Trans-Golgi Network Cytoplasmic Vesicle Autophagosome Recycling Endosome Found In The Perinuclear Region And Associates With The Golgi Apparatus Colocalizes With Myo6 And Rab8 At The Golgi Complex And In Vesicular Structures Close To The Plasma Membrane Localizes To Lc3-Positive Cytoplasmic Vesicles Upon Induction Of Autophagy
Alternative ELISA Names	Optineurin ELISA kit Optn ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance