General Info
| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 5.8pg/mL |
| Detection Limit: | 15.6-1000pg/mL |
| Short Description: | This MDC Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
Information
| Gene Symbol: | Adam11 |
| Gene ID: | 11488 |
| Uniprot ID: | ADA11_MOUSE |
| Sample Type: | serum, plasma or other biological fluids. |
Description
| Tissue Specificity | Abundantly expressed in cerebellar cortex basket cell terminals and pinceaux, weakly expressed in Purkinje cells (at protein level). Weakly expressed in the heart. Abundantly in expressed in neurons throughout the central nervous system including the telencephalon, diencephalic and brainstem nuclei, cerebellum and spinal cord. Expressed in the peripheral nervous system trigeminal and dorsal root ganglia. Expressed in the ganglion and bipolar cells of the retinae and weakly in the cornea of the eyes. Expressed in the hepatocytes of the parenchyma and hepatic lobules of the liver. Expressed in distinct focal areas in the juxtamedullary cortex of the kidney. Expressed in spermatocytes in the seminiferous tubules of the testes. Expressed in the stratum spinosum of the stratified squamous epithelia of the tongue and esophagus. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Required for localization of the potassium channel subunit proteins KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals, is thereby involved in ephaptic inhibitory synchronization of Purkinje cell firing and response to stress. Plays a role in spatial learning and motor coordination. Involved in the nociceptive pain response to chemical-derived stimulation. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 11Adam 11Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich ProteinMdc |
| Database Links | Reactome: R-MMU-5682910 |
| Cellular Localisation | Presynaptic Cell MembraneSingle-Pass Type I Membrane ProteinPerikaryonCell ProjectionAxonLocalizes To Basket Cell Terminals And Pinceaux |
| Alternative ELISA Names | Disintegrin And Metalloproteinase Domain-Containing Protein 11 ELISA kitAdam 11 ELISA kitMetalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein ELISA kitMdc ELISA kitAdam11 ELISA kitMdc ELISA kit |
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Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance